Cutting-edge AFM-RAMAN-SICM System for Biological and Local Electrochemical Studies.It allows to provide non-contact imaging of living cells and jelly surfaces measurements of mechanical properties in a wide range of stiffness, as well as patch-clamp measurements with nanometer localization. Noncontact algorithm of hopping SICM enables stable, fast and high-resolution imaging of soft and highly corrugated objects with high resolution in fluid. High-resolution AFM microscopy is available by means of Contact, Tapping and HybriD modes and is empowered by lowest signal- to-noise ratio of OBD loop on the market down to 25 fm/√Hz.